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HPV Vaccination Completion Among Men Who Have Sex with Men Using HIV Pre-Exposure Prophylaxis in Brazil: A
Alvaro Francisco Lopes de Sousa1,2, Lariane Angel Cepas3, Isadora Silva de Carvalho3
1Campus de Três Lagoas, Universidade Federal de Mato Grosso do Sul, Três Lagoas 79070-900, MS, Brazil.
Complete HPV vaccination is achieved by 59.4% of men who have sex with men (MSM) using HIV pre-exposure prophylaxis (PrEP) in Brazil. Factors like having casual partners and using lubricant were linked to higher vaccination rates.
Area of Science:
- Public Health
- Epidemiology
- Infectious Disease Prevention
Background:
- Men who have sex with men (MSM) using HIV pre-exposure prophylaxis (PrEP) face a high burden of human papillomavirus (HPV) infection.
- Data on HPV vaccination completion among this key population in Brazil are limited.
Purpose of the Study:
- To determine the prevalence of complete HPV vaccination among MSM using PrEP in Brazil.
- To identify factors associated with HPV vaccination completion in this demographic.
Main Methods:
- A cross-sectional online survey was conducted from May to September 2025.
- Participants included 872 MSM (≥18 years) in Brazil using oral PrEP, recruited via social media and gay geosocial apps.
- Data on sociodemographics, sexual behavior, and STI history were collected; complete vaccination was self-reported.
Main Results:
- Overall, 59.4% of MSM using PrEP reported complete HPV vaccination.
- Complete vaccination was associated with having steady and/or casual partners, lubricant use, and recent chlamydia/gonorrhea diagnoses.
Conclusions:
- HPV vaccination coverage is higher in Brazilian MSM using PrEP compared to the general MSM population but remains suboptimal.
- Integrating HPV vaccination assessment and delivery into PrEP care could improve completion rates and reduce HPV-related disease burden.
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