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Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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Related Experiment Video

Updated: Jan 29, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

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Published on: March 1, 2013

Polymeric Nanoparticles: A Promising Pharmaceutical Approach for Advanced Drug Delivery Systems.

Niharika Lal¹, Vaibhav Rastogi², Rosaline Mishra¹

¹Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, Uttar Pradesh, 201308, India.

Pharmaceutical Nanotechnology

|January 28, 2026

Summary

Polymeric nanoparticles (PNPs) offer precise drug delivery, improving treatment for diseases like cancer. These advanced nanocarriers enhance therapeutic efficacy and reduce side effects, paving the way for personalized medicine.

Keywords:

Drug delivery bioavailability.diagnosis formulation nanomedicine polymeric nanocarriers

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Nanotechnology revolutionizes drug delivery with precise, site-specific transport.
Polymeric nanoparticles (PNPs) are biodegradable, biocompatible nanocarriers overcoming physiological barriers.
PNPs encapsulate diverse therapeutics for controlled release, enhancing outcomes and minimizing toxicity.

Purpose of the Study:

To review synthesis, characterization, and biomedical applications of polymeric nanoparticles.
To highlight strategies for enhancing targeted delivery and therapeutic efficacy of PNPs.
To discuss challenges and future prospects of PNPs in medicine.

Main Methods:

Exploration of PNP synthesis techniques (solvent evaporation, nanoprecipitation, etc.).
Discussion of key formulation parameters and advanced characterization tools.
Review of biomedical applications, including brain targeting, cancer therapy, and regenerative medicine.

Main Results:

PNPs exhibit tunable physicochemical properties for enhanced bioavailability and targeted delivery.
Surface modification and stimuli-responsive systems improve PNP targeting and efficacy.
PNPs show significant potential in treating cancer, neurodegenerative disorders, and infections.

Conclusions:

Polymeric nanoparticles represent a promising platform for advanced drug delivery systems.
Addressing challenges in production, regulation, and safety is crucial for clinical translation.
PNPs hold potential to revolutionize medicine through personalized and efficient therapies.