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Injectable Therapy for Androgenetic Alopecia: A Systematic Review.

Jacob Beer1,2, Tanya Boghosian3, Hannah Mendez4

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Summary
This summary is machine-generated.

Injectable therapies show potential cosmetic benefits for androgenetic alopecia (AGA), but evidence is limited. Further standardized trials are needed to confirm efficacy and safety for routine use in hair loss treatment.

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Area of Science:

  • Dermatology
  • Hair Restoration Science

Background:

  • Androgenetic alopecia (AGA) is a primary cause of patterned hair loss.
  • Injectable therapies offer intradermal delivery of bioactive agents for AGA.
  • Current injectable therapy protocols and outcomes for AGA are inconsistent.

Purpose of the Study:

  • To systematically review agents, techniques, efficacy, and adverse effects of injectable therapy for AGA.
  • Evaluate the current landscape of injectable treatments for patterned hair loss.

Main Methods:

  • Systematic review conducted in July 2025, adhering to PRISMA guidelines.
  • Searched PubMed, Embase, and Scopus for studies on "mesotherapy" and "AGA."
  • Included 30 studies (7 interventional, 11 observational, 12 descriptive).

Main Results:

  • Multivitamin/peptide formulations were most common, followed by dutasteride, minoxidil, and growth factors.
  • Techniques varied significantly in needle type, depth, and dosing.
  • Reported benefits include increased hair density and diameter; mild adverse events occurred.

Conclusions:

  • Injectable therapy may offer cosmetic improvement for AGA, especially with dutasteride.
  • Limited evidence due to small sample sizes, variable protocols, and short follow-up.
  • Standardized randomized trials are necessary before routine recommendation.