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Updated: Jan 31, 2026

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
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Published on: April 17, 2014

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Integrin Signaling and ECM Proteins in hPSC Maintenance and Differentiation

Tianchen Wei1,2, Zack Z Wang1

  • 1Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Frontiers in Bioscience (Landmark Edition)
|January 29, 2026
PubMed
Summary

Integrin signaling and extracellular matrix interactions are key to human pluripotent stem cell (hPSC) self-renewal and differentiation. Defined culture systems enhance hPSC expansion for regenerative medicine applications.

Keywords:
differentiationextracellular matrix (ECM)human pluripotent stem cellsintegrinsmechanotransductionpluripotency

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