Related Experiment Video
Updated: Jan 31, 2026

05:00
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
Published on: April 1, 2019
15.6K
LipiFlow and the Transformation of Therapeutic Meibomian Gland Expression into Routine Clinical Practice
Caroline A Blackie1, David Murakami2, Eric Donnenfeld3
1Johnson & Johnson Surgical Vision, Inc., Irvine, CA, 92618, USA. cblackie@its.jnj.com.
Ophthalmology and Therapy
|January 29, 2026
Summary
Meibomian gland dysfunction (MGD) management evolved significantly after 2011. In-office treatments like LipiFlow have become an evidence-based standard of care, improving ocular symptoms and gland expression.
Area of Science:
- Ophthalmology
- Ocular Surface Disease
- Meibomian Gland Dysfunction
Background:
- Meibomian gland dysfunction (MGD) was officially recognized as a treatable condition in 2011, marking a turning point in understanding and management.
- Post-2011, research into MGD and its treatment modalities saw exponential growth.
- Therapeutic gland expression, though beneficial, was historically underutilized.
Purpose of the Study:
- To inform clinicians about the value of in-office LipiFlow treatments for MGD.
- To compare LipiFlow with other treatment modalities regarding efficacy, patient/doctor experience, compliance, and safety.
- To describe LipiFlow's role in establishing gland expression as a standard of care.
Main Methods:
- Commentary synthesizing existing research and clinical insights on MGD treatments.
- Focus on in-office thermal pulsation therapy (LipiFlow) versus other interventions.
- Evaluation of treatment outcomes, patient experience, adherence, and safety profiles.
Main Results:
- LipiFlow Thermal Pulsation System has transformed MGD management.
- It elevated therapeutic gland expression from an underutilized method to a widely adopted, evidence-based standard.
- The commentary highlights differences in efficacy, experience, compliance, and safety compared to other modalities.
Conclusions:
- In-office LipiFlow treatment is a valuable advancement in managing MGD.
- It offers distinct advantages in efficacy, patient experience, compliance, and safety.
- LipiFlow has solidified its role as a key component of modern MGD care.
Related Concept Videos
Equivalent Circuits for Practical Transformers
1.4K
The practical equivalent circuits of single-phase two-winding transformers exhibit significant deviations from their idealized versions due to the inherent properties of winding resistance and finite core permeability. These properties result in real and reactive power losses, affecting the transformer's performance. Understanding these deviations is crucial for designing more efficient transformers.
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
1.4K
Bacterial Transformation
59.9K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.9K
Exocrine Glands: Unicellular and Multicellular Glands
32.5K
Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
32.5K
Transformers
1.8K
A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
1.8K
Transformation
1.1K
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
1.1K
Therapeutic Index
6.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
