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Developing Patient-Centered Clinical Trials: Implications for Incorporating Patient Perspectives.

Deena Sukhon1,2,3, Sarah E Bradley1,2, Alexander K Hallway1,2

  • 1Department of Surgery, Michigan Medicine, Ann Arbor, Michigan.

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|January 30, 2026
PubMed
Summary
This summary is machine-generated.

Female patients prioritize nonoperative hernia treatments and quality of life outcomes in clinical trials. Their input is crucial for designing patient-centered surgical research that aligns with individual needs and preferences.

Keywords:
clinical trialsfemale patientsgroin herniapatient engagementpatient outcomespatient-centered researchtrial design

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Area of Science:

  • Surgical research
  • Patient-centered care
  • Qualitative research methodology

Background:

  • Clinical trials are essential for advancing surgical research.
  • Ensuring surgical research aligns with patient priorities is critical for relevance and efficacy.
  • Groin hernias represent a common surgical condition where patient perspectives can inform research direction.

Purpose of the Study:

  • To explore female patients' perspectives on research priorities for groin hernias.
  • To understand patient preferences regarding clinical trial participation.
  • To identify key outcomes important to patients undergoing evaluation for groin hernias.

Main Methods:

  • An exploratory qualitative study design was employed.
  • Semi-structured interviews were conducted with 34 female patients.
  • Grounded theory principles guided data analysis to identify emergent themes.

Main Results:

  • Patients expressed significant interest in nonoperative management options.
  • A strong willingness to participate in clinical trials was reported.
  • Key outcomes of importance included pain management, recovery speed, and overall quality of life.

Conclusions:

  • Patient-centered approaches are vital for designing relevant surgical trials.
  • Incorporating patient priorities, such as nonoperative options and quality of life, enhances trial design.
  • Future surgical research, particularly for groin hernias, should actively involve patient perspectives to ensure alignment with patient needs.