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Updated: Jan 31, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper/Photoredox Dual Catalysis for the Redox-Neutral C(sp3)-CF2H Cross-Coupling between Benzylic Bromides and
Xiangxue Cao1, Ge Lan2, Zhenyu Wang3
1School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, Shihezi University, Shihezi 832003, China.
Abstract:
A copper/photoredox dual-catalytic strategy has been developed for radical-radical C(sp3)-CF2H cross-coupling between alkyl bromides and readily accessible tetracoordinated difluoromethylborates. In this protocol, visible-light-induced single-electron oxidation of the borates generates difluoromethyl radicals (•CF2H), which are subsequently intercepted by a copper catalyst to forge C(sp3)-CF2H bonds. This redox-neutral approach proceeds without the need for stoichiometric halogen atom transfer (XAT) reagents, oxidants, or reductants, exhibits broad functional group tolerance, and enables late-stage installation of the pharmaceutically privileged CF2H motif into aliphatic frameworks.
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