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Updated: Feb 1, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Anthracene-Bridged Cyclo[3]Dipyrrin Exhibiting Induced Chirality and Its Conformationally Asymmetric Tris-BODIPY
Anjana Prasad Nambiar1, Aswini Spergen1, Gokulnath Sabapathi1
1School of Chemistry, Indian Institute of Science Education and Research, Thiruvananathapuram, Kerala, India.
Abstract:
This work explores the synthesis of Cyclo[3]mer 1a obtained by the acid-catalyzed condensation reaction of 1,5-di(1H-pyrrol-2-yl)anthracene with pentafluorobenzaldehyde in the presence of trifluoroacetic acid. Because of the larger cavity size and multiple sites for coordination, cyclo[3]mer underwent smooth BF2 complexation which showed a triangle-like conformation based on the DFT optimization results. DFT analysis and solution state 1H NMR studies reveal the twisted C3 symmetric structure of the macrocycle 1a. Upon addition of enantiopure D and L mandelic acids, macrocycle 1a showed chiral response in CD spectra due to chirality induction.
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