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Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: Addressing Technical and Subjective Challenges in Measuring Classroom Attention
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An immune-inspired intelligent aptasensor with broad detection capability.

Nan Li1, Kaiyue Wei1, Yuyang Zhang1

  • 1State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, PR China; Qingdao Key Laboratory of Food Biotechnology, Qingdao 266404, PR China; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, Qingdao 266404, PR China.

Trends in Biotechnology
|January 31, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces an immune-inspired biomimetic strategy for aptamer engineering, significantly enhancing biosensor performance. The novel approach enables rapid, accurate detection of trace food contaminants using smartphone-based analysis.

Keywords:
aptasensorbiomimetic nanozymebiosensorfood contaminants detectionimmune-inspired aptamer engineeringsmartphone-based biosensing

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Area of Science:

  • Biomimetic biosensing
  • Aptasensor development
  • Nanozyme engineering

Background:

  • Conventional aptasensors face limitations due to suboptimal aptamers and material combinations.
  • There is a need for advanced biosensing strategies for rapid diagnostics.

Purpose of the Study:

  • To pioneer a biomimetic strategy using V(D)J recombination for aptamer engineering.
  • To develop a novel biosensing platform for high-throughput screening of food contaminants.
  • To enhance the binding affinity and detection limits of aptasensors.

Main Methods:

  • Immune-inspired biomimetic strategy harnessing V(D)J recombination for aptamer engineering.
  • Development of topology-refactored aptamers with enhanced binding affinity.
  • Utilizing DNA nanosphere-Cu(II) biomimetic nanozymes regulated by target-aptamer binding.
  • Integration with smartphone-based colorimetric analysis for detection.

Main Results:

  • Topology-refactored aptamers showed a 133.3-fold enhancement in binding affinity.
  • The biosensing platform achieved ultra-low limits of detection for various contaminants (e.g., 104.0 pM for cadmium).
  • Demonstrated high accuracy and broad detection capability in complex real-world samples.

Conclusions:

  • The biomimetic strategy redefines aptamer design, leading to robust and nature-inspired biosensors.
  • This approach offers new possibilities for developing advanced biosensors for practical applications.
  • The developed platform enables efficient and sensitive detection of trace food contaminants.