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Updated: Feb 3, 2026

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
Published on: July 23, 2016
Highly Regioselective Hydroaminomethylation for Amine Synthesis Enabled by a Heterogeneous Molecular Catalyst
Zhaozhan Wang1,2, Yinghao Zhu1, Bhalchandra M Bhanage3
1Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Abstract:
In this work, we report an efficient protocol for direct amine synthesis from alkenes catalyzed by a heterogeneous molecular catalyst Ru3/QDPOP, which features well-defined trinuclear Rh centers stabilized by a phosphine-functionalized porous organic polymer. The catalyst exhibited high activity and excellent regioselectivity toward the desired linear amines, significantly surpassing previously reported homo- and heterogeneous Ru-based catalysts. Various secondary and tertiary amines, including pharmaceutically relevant compounds, can be effectively synthesized from diverse amines and alkenes under mild conditions. Moreover, the catalyst is stable and recyclable, maintaining high performance over five cycles without appreciable loss in performance.
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