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We developed a novel aptasensor using copper nanoparticles and a light-addressable potentiometric sensor for sensitive Interleukin-6 (IL-6) detection. This biosensor offers a low detection limit and high stability for potential clinical diagnostics.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Interleukin-6 (IL-6) is a key biomarker for inflammatory diseases and cancer.
  • Accurate and sensitive IL-6 detection is crucial for disease monitoring and diagnosis.
  • Existing detection methods may lack sensitivity, selectivity, or require complex procedures.

Purpose of the Study:

  • To develop a novel, label-free aptasensor for highly sensitive Interleukin-6 (IL-6) detection.
  • To leverage copper nanoparticles (CuNPs) and a light-addressable potentiometric sensor (LAPS) for enhanced signal transduction.
  • To evaluate the sensor's performance characteristics, including sensitivity, selectivity, stability, and applicability in biological samples.

Main Methods:

  • Fabrication of a LAPS-based aptasensor functionalized with IL-6 specific aptamers.
  • Integration of copper nanoparticles (CuNPs) to enhance electron transfer and signal amplification.
  • Characterization of sensor performance using electrochemical measurements and analysis of potential shifts upon IL-6 binding.
  • Testing sensor selectivity against interfering substances and evaluating stability and reproducibility.
  • Validation of the sensor using spiked human serum samples.

Main Results:

  • The CuNP-LAPS aptasensor demonstrated highly sensitive and label-free detection of IL-6.
  • A low limit of detection (LOD) of 2.1 pg/mL was achieved within a linear range of 5 to 200 ng/mL.
  • The sensor exhibited excellent selectivity, stability, and reproducibility.
  • Successful detection of IL-6 in spiked human serum samples confirmed the sensor's clinical potential.

Conclusions:

  • The developed CuNP-LAPS aptasensor offers a promising platform for sensitive and reliable IL-6 quantification.
  • This novel biosensor holds significant potential for advancing early diagnosis and monitoring of inflammatory conditions and cancers.
  • The label-free and robust nature of the sensor facilitates practical clinical diagnostic applications.