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Updated: Feb 4, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of Six-Membered Ring Nucleoside Analogues through the Palladium-Catalyzed Tandem Allylic Substitution
Ke-Xin Huang1, Ke-Xin Zhang1, Cai-Jing Li1
1School of Biological and Chemical Engineering, Institute of Biology and Pharmaceutical Research, Nanyang Institute of Technology, Nanyang, Henan 473000, China.
Abstract:
We have developed an efficient Pd-catalyzed tandem allylic substitution reaction for the synthesis of six-membered ring nucleoside analogues. This strategy employs α-purine-substituted acetophenones (α-purine-substituted acetone) as challenging dinucleophiles, which react with 2-methylenepropane-1,3-diyl diacetate to afford the corresponding products in high yields (up to 91%) across a broad range of substrates (21 examples). The use of commercially available catalysts, a broad substrate scope, and the potential application value of the products make this approach highly attractive and pioneering in the field.
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