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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Related Experiment Video

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Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Sepsis and the immunometabolic inflammatory response.

Samuel N Paul1, Isabell Nessel1, Zudin Puthucheary1,2

  • 1Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.

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Sepsis causes immune and metabolic disruption, leading to severe illness. Understanding leukocyte immunometabolism offers new ways to track immune function and improve sepsis diagnosis and treatment.

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Area of Science:

  • Immunology
  • Metabolic research
  • Critical care medicine

Background:

  • Sepsis is a life-threatening condition involving immune dysregulation, inflammation, and metabolic issues.
  • Current prognostic tools focus on organ damage, not immune cell metabolic status.
  • Improved mechanistic insight into sepsis is crucial due to its high morbidity and mortality.

Purpose of the Study:

  • To review the role of leukocyte immunometabolism in sepsis pathophysiology.
  • To highlight the potential of immunometabolic profiling for patient monitoring.
  • To explore how this approach can advance biomarker-driven precision medicine in sepsis.

Main Methods:

  • Literature review of current knowledge on leukocyte metabolic dysfunction in sepsis.
  • Discussion of emerging technologies for high-resolution immunometabolic profiling.
  • Integration of immunometabolic data for diagnostic and monitoring applications.

Main Results:

  • Leukocyte metabolic dysfunction is a key feature of sepsis.
  • High-resolution immunometabolic profiling can reveal critical insights into immune cell function.
  • Integrating these profiles may lead to novel metabolic biomarkers.

Conclusions:

  • Immunometabolism provides a vital framework for understanding sepsis.
  • Immunometabolic profiling holds promise for refining sepsis diagnostics and patient monitoring.
  • This approach can drive the development of precision medicine strategies for sepsis.