Sepsis and the immunometabolic inflammatory response

Area of Science:

• Immunology
• Metabolic research
• Critical care medicine

Background:

• Sepsis is a life-threatening condition involving immune dysregulation, inflammation, and metabolic issues.
• Current prognostic tools focus on organ damage, not immune cell metabolic status.
• Improved mechanistic insight into sepsis is crucial due to its high morbidity and mortality.

Purpose of the Study:

• To review the role of leukocyte immunometabolism in sepsis pathophysiology.
• To highlight the potential of immunometabolic profiling for patient monitoring.
• To explore how this approach can advance biomarker-driven precision medicine in sepsis.

Main Methods:

• Literature review of current knowledge on leukocyte metabolic dysfunction in sepsis.
• Discussion of emerging technologies for high-resolution immunometabolic profiling.
• Integration of immunometabolic data for diagnostic and monitoring applications.

Main Results:

• Leukocyte metabolic dysfunction is a key feature of sepsis.
• High-resolution immunometabolic profiling can reveal critical insights into immune cell function.
• Integrating these profiles may lead to novel metabolic biomarkers.

Conclusions:

• Immunometabolism provides a vital framework for understanding sepsis.
• Immunometabolic profiling holds promise for refining sepsis diagnostics and patient monitoring.
• This approach can drive the development of precision medicine strategies for sepsis.