Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Special Staining Techniques

Special Staining Techniques

Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...

Introduction to Special Senses

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...

Network Covalent Solids

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...

Specialized Characteristics of Cardiac Muscles

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polystyrene Microplastics Activate Noncanonical TGF‑β Signaling and Metabolomic Reprogramming to Promote Epithelial-Mesenchymal Transition and Fibrosis in the Kidney.

ACS omega·2026

Same author

Hierarchical Network Adaptations and Structure-Function Scaffolding in the Deaf Adult Brain.

Brain topography·2026

Same author

Localized cortical morphometric and structural covariance differences in adolescents with functional/dissociative seizures.

Epilepsia·2026

Same author

Insights from NMR - based metabolomics elucidates key metabolic dysregulation in pancreatitis-induced acute respiratory distress syndrome: A step towards precision medicine.

Biophysical chemistry·2026

Same author

Dehydration-Induced Motional Heterogeneity in Native Collagen Protein Probed by Solid-State NMR Spectroscopy.

Biomacromolecules·2026

Same author

Serum metabolomic profiling by <sup>1</sup>H NMR reveals distinct metabolic signatures in diabetic and non-diabetic chronic kidney disease.

Biophysical chemistry·2026

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP

Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP

Published on: April 20, 2015

Limbic-Visual Disintegration and Salience-Control Specialization Characterize Tinnitus Network Topology.

Himanshu R Pandey^1,2, Amit Keshri³, Neeraj Sinha^1,2

¹Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, India.

The European Journal of Neuroscience

|February 3, 2026

Summary

Subjective tinnitus (ST) involves specific brain network changes, not global ones. These include altered connectivity in visual, limbic, and salience networks, linked to symptom severity and anxiety.

Keywords:

amygdala graph theory network‐based statistics resting‐state fMRI salience network tinnitus voxel‐based morphometry

More Related Videos

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Published on: July 27, 2011

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Related Experiment Videos

Last Updated: Feb 4, 2026

Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP

Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP

Published on: April 20, 2015

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Visualization of the Interstitial Cells of Cajal ICC Network in Mice

Published on: July 27, 2011

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

Area of Science:

Neuroscience
Medical Imaging
Psychiatry

Background:

Subjective tinnitus (ST) is thought to stem from large-scale brain network reorganization.
The specific brain circuits involved and how they relate to symptom severity remain unclear.

Purpose of the Study:

To investigate the precise brain network alterations associated with subjective tinnitus.
To explore the relationship between tinnitus severity, anxiety, and specific network connectivity patterns.
To identify potential neuroimaging markers for patient stratification and treatment targeting in ST.

Main Methods:

Combined resting-state fMRI (graph theory, ROI-to-ROI connectivity) and VBM in 114 participants (57 ST, 57 controls).
Utilized a harmonized 50-ROI parcellation from the CONN atlas across 15 functional networks.
Employed multivariate modeling and node-wise analyses, controlling for covariates and multiple comparisons.

Main Results:

Identified selective, not global, network reorganization in ST patients.
Observed reduced integration in the left posterior parahippocampal gyrus and increased segregation in frontal/insular hubs.
Found hyperconnectivity in fronto-salience-language-cerebellar circuits and hypoconnectivity in default mode/dorsal attention pathways.
Linked higher tinnitus severity to reduced medial visual/limbic integration and increased frontal-temporal opercular connectivity.
Associated higher anxiety with increased integration in subcallosal/cerebellar/occipito-limbic areas and decreased putamen connectivity.
VBM revealed widespread white-matter reductions in specific brain regions.

Conclusions:

Subjective tinnitus is characterized by targeted network reorganization, specifically reduced medial temporal/visual-limbic integration and increased local specialization.
These findings provide strong evidence for ST reflecting specific circuit alterations rather than global brain changes.
The identified multimodal, symptom-linked signatures offer actionable circuit markers for clinical applications in ST.