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Updated: Feb 5, 2026

Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods
Published on: February 11, 2016
Iridium-Catalyzed Desymmetric Hydroalkynylation of Cyclopentenes to Construct 1,3-Stereocenters
Tong Wan1, En-Ze Lin2, Huanrong Li1
1Department of Chemistry, Renmin University of China, Beijing 100872, China.
Abstract:
Transition metal-catalyzed enantioselective alkene hydroalkynylation to construct a nonadjacent stereocenter, especially in cyclic systems, remains underexplored. Herein, we report an iridium-catalyzed enantioselective hydroalkynylation of cyclopentene substrates containing an amide as the directing group, affording cyclopentanes with nonadjacent 1,3-stereocenters with high regio-, diastereo-, and enantioselectivity. The alkynyl group in the product enables further transformations, providing a reliable route to enantioenriched cyclic compounds with nonadjacent stereocenters.
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