Clinical Analysis of Primary Prostatic Diffuse Large B-Cell Lymphoma

Given the extreme rarity of primary diffuse large B-cell lymphoma of the prostate (P-DLBCL-P), medical institutions face challenges in accumulating a sufficient number of cases. Thus, investigating the clinical manifestations of this disease and exploring potential therapeutic strategies holds significant importance.

We present three cases of P-DLBCL-P, all admitted to our hospital with symptoms of lower urinary tract obstruction. Following pathological examination of the prostate, all three patients were definitively diagnosed with P-DLBCL-P.

Case 1 discharged himself from the hospital after refusing treatment. Case 2 received eight courses of R-CDOP regimen chemotherapy but died of rectovesical fistula. Case 3 developed obstructive nephropathy due to urinary tract obstruction and died soon after emergency dialysis.

P-DLBCL-P is an extremely rare disease that is prone to misdiagnosis, emphasizing the need to pay close attention to its clinical manifestations for prompt and accurate diagnosis. All three patients in this study received timely diagnoses, but one refused treatment, and the other two experienced disease progression despite appropriate intervention. Given the limited clinical data on this disease, more cases are required to explore the prognosis of patients and the efficacy of various therapeutic strategies, including emerging treatment options.