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Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Termination of Translation

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...

Termination of Translation

Termination of Translation

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Screw: Problem Solving

Screw: Problem Solving

In mechanical engineering, the interaction between a threaded screw shaft and a plate gear involves analyzing the resisting torque on the plate gear that can be overpowered when a specific torsional moment is applied to the shaft. To better comprehend this concept, consider a generic situation with a threaded screw shaft with a given mean radius and lead and a plate gear with a specified mean radius. The coefficient of static friction between the screw and gear is also provided.
To evaluate the...

Self-Locking Screw

Self-Locking Screw

A square-threaded screw jack is a mechanical device widely used for lifting heavy loads or applying considerable force. One of the key features that can make a screw jack more effective and reliable is its self-locking capability.
A square-threaded screw jack carrying a load is considered self-locking if the screw retains its position even after the moment applied to it is removed.

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Experimental Model of Ligature-Induced Peri-Implantitis in Mice

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Screwing the helical chirality through terminal peri-functionalization.

Devesh Chandra¹, Sachin^1,2, Upendra Sharma^1,2

¹Chemical Technology Division, CSIR-IHBT, Palampur, HP 176 061, India.

Beilstein Journal of Organic Chemistry

|February 4, 2026

Summary

This summary is machine-generated.

Helical chirality, crucial in biology and materials, is generated via cycloaddition or novel peri-functionalization. This review highlights advancements in creating these chiral helical architectures.

Keywords:

C–H functionalization catalysis helical chirality

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Area of Science:

Organic Chemistry
Stereochemistry
Materials Science

Background:

Helical chirality is a significant, yet underappreciated, form of molecular chirality.
Molecules exhibiting helical chirality play vital roles in biological processes and advanced materials.
Traditional methods for generating helical chirality involve ring expansion via cycloaddition reactions.

Purpose of the Study:

To review key advancements in generating helical chiral architectures.
To highlight parallel approaches, including classical and novel methods.
To underscore the importance of helical chirality in chemistry and beyond.

Main Methods:

Review of classical cycloaddition and related reactions for helical structure generation.
Exploration of the emerging peri-functionalization approach for chiral helicity.
Synthesis and analysis of molecular architectures with helical chirality.

Main Results:

Cycloaddition reactions provide established routes to helical molecules.
Peri-functionalization offers a new and effective pathway for generating chiral helical molecules.
Both approaches contribute to the diverse toolkit for synthesizing helical chiral architectures.

Conclusions:

Significant progress has been made in synthesizing helical chiral molecules.
The peri-functionalization approach represents a notable recent advancement.
Understanding and controlling helical chirality is key for biological and materials applications.