Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Trigonometric Identities II01:28

Trigonometric Identities II

424
Double-angle and half-angle trigonometric identities are derived from the fundamental sum and difference formulas and serve as essential tools for simplifying expressions, solving equations, and evaluating integrals. These identities reduce the complexity of trigonometric functions by relating functions of a multiple or fractional angle to functions of a single angle. Their applications extend across mathematics, physics, and engineering, particularly in Fourier analysis, wave mechanics, and...
424
Personal Identity01:25

Personal Identity

413
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
413
Social Identity01:29

Social Identity

318
Social identity constitutes a significant aspect of an individual’s self-concept, shaped by membership in various social groups, including gender, nationality, ethnicity, sexual orientation, and political affiliation. Individuals associate specific traits with particular social groups, leading to internalization of these traits. For example, musicians are often perceived as creative, while women are frequently associated with nurturing tendencies. Once individuals identify with a...
318
Trigonometric Identities I01:27

Trigonometric Identities I

243
Trigonometric identities are equations that relate trigonometric functions and hold for all angles within their domains. A fundamental identity among these is the Pythagorean identity, which arises directly from the geometry of the unit circle. For any angle θ, a point on the unit circle has coordinates (cos⁡ θ, sin ⁡θ), and since the radius of the circle is one, the Pythagorean Theorem gives:This identity serves as the basis for deriving additional identities.
243
Marcia's Theory of Identity Status01:26

Marcia's Theory of Identity Status

1.6K
James Marcia's identity status model provides a framework for understanding how adolescents navigate identity formation through varying degrees of exploration and commitment. Marcia's model builds on Erik Erikson's theories of psychosocial development, focusing specifically on how adolescents reconcile individual aspirations with societal expectations. His model describes identity formation as a dynamic process where adolescents move between different states depending on their level...
1.6K
Role-Based Identity01:21

Role-Based Identity

211
Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
211

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1.

The EMBO journal·2026
Same author

Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing.

bioRxiv : the preprint server for biology·2026
Same author

Centromeres are hotspots of cytosine methylation epimutations in a filamentous fungus.

bioRxiv : the preprint server for biology·2026
Same author

EMBO Press co-evolves with molecular ecology and evolutionary biology.

The EMBO journal·2026
Same author

Epimutations: raw material for evolution?

The EMBO journal·2026
Same author

Design and implementation of blood donor sample bioarchives to enhance preparedness for emerging and pandemic pathogens in England.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2025

Related Experiment Video

Updated: Feb 7, 2026

Basic Caenorhabditis elegans Methods: Synchronization and Observation
11:34

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Published on: June 10, 2012

49.5K

ATRX safeguards cellular identity during C. elegans development.

Janie Olver1,2, Mariya Shtumpf1, Karim Hussain1,3

  • 1School of Biology, University of St Andrews, St Andrews, UK.

Biorxiv : the Preprint Server for Biology
|February 6, 2026
PubMed
Summary

Loss of the ATRX protein (XNP-1 in worms) causes developmental and telomere issues by allowing germline genes to inappropriately activate. Suppressing this activation rescues most observed phenotypes.

More Related Videos

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans
05:11

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans

Published on: July 12, 2024

1.0K
Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

10.4K

Related Experiment Videos

Last Updated: Feb 7, 2026

Basic Caenorhabditis elegans Methods: Synchronization and Observation
11:34

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Published on: June 10, 2012

49.5K
In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans
05:11

In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans

Published on: July 12, 2024

1.0K
Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

10.4K

Area of Science:

  • Genetics
  • Molecular Biology
  • Developmental Biology

Background:

  • ATRX is an ATP-dependent chromatin remodeler implicated in human ATRX syndrome.
  • ATRX dysfunction in humans is linked to neurodevelopmental disorders, alternative lengthening of telomeres (ALT), retrotransposon upregulation, and replication stress sensitivity.
  • The precise function of ATRX and the basis for its diverse mutation-associated phenotypes remain unclear.

Purpose of the Study:

  • To investigate the role of ATRX in the model organism Caenorhabditis elegans.
  • To determine the underlying mechanisms driving ATRX-associated phenotypes.

Main Methods:

  • Studied the C. elegans homologue of ATRX, XNP-1.
  • Analyzed phenotypes in xnp-1 mutant animals.
  • Investigated the genetic interaction between xnp-1 and the germline transcription factor gsox-1.

Main Results:

  • Loss of XNP-1 recapitulates many human ATRX phenotypes.
  • XNP-1 is essential for repressing inappropriate germline gene activation.
  • Germline gene misexpression in xnp-1 mutants correlates with observed phenotypes, including developmental abnormalities and telomeric defects.
  • Mutation of gsox-1 suppresses xnp-1 phenotypes, indicating a link between germline transcription and ATRX function.

Conclusions:

  • The majority of XNP-1/ATRX-dependent phenotypes stem from its role in maintaining cellular identity by repressing germline gene expression.
  • These findings provide insights into the fundamental functions of ATRX in human health and disease.