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Updated: Feb 7, 2026
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Association Between the Modified Frailty Index-5 and Clinical Outcomes in Burn Patients
Jule Schmiechen1,2, Thomas Kremer3, Susanne Rein1,2
1Department of Trauma Surgery and Orthopedics, University Hospital Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, Germany.
Summary
The modified Frailty Index (mFI-5) effectively predicts adverse outcomes in burn patients, including longer hospital stays and increased complications. This simple tool aids risk stratification in burn centers.
Area of Science:
- Trauma and Burn Care
- Geriatric Medicine
- Health Services Research
Background:
- Frailty increases vulnerability to stressors and adverse health outcomes.
- The modified Frailty Index (mFI-5) uses five comorbidities to predict outcomes.
- mFI-5 has demonstrated predictive value for treatment outcomes and mortality.
Purpose of the Study:
- Evaluate clinical outcome differences in burn patients based on mFI-5 scores (0, 1, and ≥2).
- Determine if mFI-5 independently predicts adverse outcomes in burn patients.
Main Methods:
- Retrospective analysis of 644 burn patients (September 2018 - May 2022).
- Analysis of comorbidities, complications, ventilation, surgeries, length of stay, and discharge destination.
- Statistical methods included chi-square, Kruskal-Wallis, and multivariate regression.
Main Results:
- Higher mFI-5 scores correlated with longer hospital stays, more complications, and increased need for ventilation and skin grafts.
- mFI-5 ≥2 independently predicted higher rates of urinary tract infections (OR 2.41).
- mFI-5=1 independently predicted non-home discharge (OR 2.34).
Conclusions:
- The modified Frailty Index (mFI-5) is a strong predictor of complications and adverse outcomes in burn patients.
- mFI-5 serves as a valuable and easily applicable risk stratification tool for specialized burn centers.
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