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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
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Primary Cutaneous Neoplasms with NUT Gene Fusions
Nicolas Macagno1, Mélanie Legrand2, Thibault Kervarrec2
1Department of Pathology, La Timone Hospital, AP-HM, Marseille, France.
Surgical Pathology Clinics
|February 6, 2026
Summary
This study investigates NUTM1 gene fusions in skin tumors like poroma and NUT carcinoma. Accurate diagnosis of primary cutaneous NUT carcinoma relies on specific tests to distinguish it from other cancers.
Area of Science:
- Oncology
- Dermatopathology
- Molecular Pathology
Background:
- NUTM1 gene fusions are implicated in various neoplasms.
- Cutaneous neoplasms present diagnostic challenges, particularly when mimicking other conditions.
Purpose of the Study:
- To examine cutaneous neoplasms associated with NUTM1 gene fusions.
- To highlight diagnostic difficulties in distinguishing primary cutaneous NUT carcinoma from similar entities.
Main Methods:
- Review of cases involving cutaneous neoplasms with NUTM1 gene fusions.
- Analysis of diagnostic criteria, including immunohistochemistry (NUT, SOX10, YAP1) and molecular testing.
Main Results:
- Poroma, porocarcinoma, and primary cutaneous NUT carcinoma are identified as entities with NUTM1 gene fusions.
- Differentiation between primary cutaneous NUT carcinoma, extracutaneous NUT carcinoma, and porocarcinoma is complex.
Conclusions:
- Immunohistochemistry and molecular testing are crucial for accurate diagnosis.
- Distinguishing primary cutaneous NUT carcinoma requires careful evaluation to differentiate it from extracutaneous NUT carcinoma and porocarcinoma.
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