Related Experiment Video
Updated: Feb 8, 2026
09:43
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
6.9K
Primary Cutaneous Carcinomas with Neuroendocrine Differentiation.
Thibault Kervarrec1, Nicolas Macagno2, Serge Guyétant3
1Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; Caraderm Network, France; Biologie des infections à polyomavirus" team, UMR INRA ISP 1282, Université de Tours, Tours, France.
Surgical Pathology Clinics
|February 6, 2026
Summary
This review covers skin tumors with a neuroendocrine phenotype, including Merkel cell carcinoma. It details their clinical, morphologic, immunohistochemical, and genetic aspects for diagnosis and management.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Neuroendocrine neoplasms occur in various organs, categorized by differentiation.
- Skin neuroendocrine tumors present unique diagnostic challenges.
Purpose of the Study:
- To summarize key features of skin neuroendocrine tumors.
- To focus on Merkel cell carcinoma and related entities.
- To aid in diagnosis, management, and differential diagnosis.
Main Methods:
- Review of clinical, morphologic, immunohistochemical, and genetic data.
- Focus on specific entities: Merkel cell carcinoma, Wnt/betacatenin rosette-forming carcinoma, endocrine mucin-producing sweat gland carcinoma, and sweat gland carcinoma with neuroendocrine differentiation.
Main Results:
- Detailed characterization of selected skin neuroendocrine tumors.
- Emphasis on diagnostic criteria and management strategies.
- Discussion of differential diagnoses for accurate identification.
Conclusions:
- Accurate diagnosis of skin neuroendocrine tumors requires integrating multiple features.
- Understanding these entities is crucial for effective patient management.
- Further research may refine diagnostic and therapeutic approaches.
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