Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Structure of Lipids03:38

Structure of Lipids

99.1K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
99.1K
Antibody Structure01:10

Antibody Structure

65.7K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.7K
Protein and Protein Structure02:15

Protein and Protein Structure

88.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
88.4K
RNA Structure01:23

RNA Structure

79.2K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
Electron Transport Chains01:28

Electron Transport Chains

112.7K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
112.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lithium-selective supramolecular assembly and capture by tripeptide gelators.

Chemical science·2026
Same author

Phase separation induced by active polymerization makes protocells robust against environmental changes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Role of Polymer Backbone Rigidity on the Solution Properties of Bioderived Poly(styrene-<i>co</i>-maleic anhydride) Derivatives.

ACS polymers Au·2026
Same author

Synthesis of Functional Water-Soluble Polyesters Based on Citric Acid and Dimethylolpropionic Acid.

ACS polymers Au·2026
Same author

Disc-Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Assembling a True "Olympic Gel" From over 16 000 Combinatorial DNA Rings.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Potentials of Machine Learning in Predicting Key Features of Synthetic Antimicrobial Polymers.

ACS polymers Au·2026
Same journal

Polymer-Grafted Nanoparticles as All-in-One Nanoplatforms.

ACS polymers Au·2026
Same journal

Impact of Ion Pairs on the Properties of Dynamic Ion Gels Formed by Complex Coacervation of Oppositely Charged Poly(Ionic Liquids).

ACS polymers Au·2026
Same journal

Toward Greener Rubber: Impact of Resin Type and Amount on Curing, Network Structure, and Viscoelastic Properties in SBR compounds.

ACS polymers Au·2026
Same journal

Mechanically Enhanced Ultrashort Peptide Hydrogels for pH-Triggered Release.

ACS polymers Au·2026
Same journal

Thermally Activated Stress Relaxation and Creep in Ideal Hydrogel Elastomers: Rupture of Tensile Strands.

ACS polymers Au·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
15:06

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

13.4K

Linking Structure and Topology in Single-Chain Nanoparticles Using Simulations and Scattering Data.

Marco Werner1, Johanna Engelke1, Ralf Schweins2

  • 1Leibniz-Institut für Polymerforschung Dresden, Hohe Strasse 6, Dresden 01069, Germany.

ACS Polymers Au
|February 9, 2026
PubMed
Summary
This summary is machine-generated.

We used simulations and small angle neutron scattering to study single-chain nanoparticles (SCNPs). We found that SCNP structure depends on cross-linker density and solvent quality, enabling predictive design of these soft nanoparticles.

Keywords:
SANScoarse grainingsequencesimulationssingle-chain nanoparticle

More Related Videos

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K
Analysis of SEC-SAXS data via EFA deconvolution and Scatter
10:59

Analysis of SEC-SAXS data via EFA deconvolution and Scatter

Published on: January 28, 2021

9.9K

Related Experiment Videos

Last Updated: Feb 10, 2026

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
15:06

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

Published on: January 3, 2016

13.4K
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K
Analysis of SEC-SAXS data via EFA deconvolution and Scatter
10:59

Analysis of SEC-SAXS data via EFA deconvolution and Scatter

Published on: January 28, 2021

9.9K

Area of Science:

  • Polymer science
  • Soft matter physics
  • Materials science

Background:

  • Single-chain nanoparticles (SCNPs) are polymers that fold into compact structures.
  • Understanding SCNP structure is crucial for designing advanced materials.
  • Previous studies have explored SCNP formation, but predictive design remains challenging.

Purpose of the Study:

  • To investigate the structure of single-chain nanoparticles (SCNPs).
  • To correlate experimental scattering data with simulation-based topological states.
  • To enable predictive design of SCNPs by understanding folding behavior.

Main Methods:

  • Small angle neutron scattering (SANS) experiments were used to probe SCNP structure.
  • Coarse-grained Monte Carlo simulations modeled the folding of poly-(pentafluorobenzyl-stat-tert-butyl acrylate) precursors.
  • Simulation results were compared with experimental SANS data to validate the model.

Main Results:

  • Simulation results closely matched experimental SANS data, particularly regarding compaction.
  • SCNP structure was found to be sensitive to cross-linker density and solvent quality.
  • Experimental SCNPs were generally in a sparse state, distinct from fractal globules, though highly compacted SCNPs showed dense sphere characteristics.

Conclusions:

  • The study successfully linked experimental scattering signatures to underlying topological states during cross-linking.
  • A predictive framework for designing soft nanoparticles was established.
  • This work facilitates tailored SCNP design by controlling solvent quality and monomer sequence.