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Coagulation Hemostasis Parameters in Macaque Monkeys (Macaca spp.).

O A Shamsutdinova1, A P Zlobina2, V V Keburiya2

  • 1National Research Centre "Kurchatov Institute", Moscow, Russia. Shamsutdinova_OA@nrcki.ru.

Bulletin of Experimental Biology and Medicine
|February 9, 2026
PubMed
Summary
This summary is machine-generated.

Coagulation hemostasis parameters in Macaca monkeys show significant age and sex differences. These findings establish crucial reference ranges for Macaca mulatta and Macaca fascicularis in research settings.

Keywords:
Macaca fascicularisMacaca mulattablood clottinghemostasis systemlaboratory animals

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Area of Science:

  • Primatology
  • Hemostasis and Thrombosis
  • Comparative Physiology

Background:

  • Coagulation hemostasis parameters are vital for understanding physiological states in non-human primates.
  • Establishing species-specific and age-stratified reference ranges is essential for accurate interpretation of laboratory data.

Purpose of the Study:

  • To assess coagulation hemostasis parameters in Macaca mulatta and Macaca fascicularis.
  • To identify interspecific variability and age- and sex-dependent differences in hemostatic parameters.
  • To establish quantitative reference ranges for these primate species.

Main Methods:

  • Hemostasis parameters were measured in Macaca mulatta and Macaca fascicularis of varying ages (1-34 years).
  • Animals were housed in open enclosures under humid subtropical climatic conditions.
  • Statistical analyses were performed to compare parameters between immature, mature, and aged individuals, as well as between sexes.

Main Results:

  • High interspecific variability in hemostatic parameters was observed among sexually mature individuals.
  • Statistically significant differences in mean coagulation parameters were found between immature and mature animals.
  • Significant sex-dependent differences in hemostasis indicators were detected in aged animals (≥20 years).

Conclusions:

  • Age and sex significantly influence coagulation hemostasis parameters in Macaca monkeys.
  • The obtained quantitative reference ranges provide a baseline for hemostasiological data interpretation in Macaca mulatta and Macaca fascicularis.
  • This study highlights the importance of considering demographic factors when evaluating hemostasis in laboratory primates.