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Atom Transfer Radical Polymerization of Functionalized Vinyl Monomers Using Perylene as a Visible Light Photocatalyst
Published on: April 22, 2016
Visible-Light-Induced Lactone-Fused Indoline Construction via Radical Dearomatization of Indoles with Alcohols
Jingshan Ai1, Qihang Xu1, Yaru Liu1
1Shandong Key Laboratory of Advanced Electrochemical Energy Storage Technologies, College of New Energy, China University of Petroleum (East China), Qingdao 266580, P. R. China.
Abstract:
We report a visible-light-induced strategy for synthesizing lactone-fused indolines via the radical dearomatization of indoles with simple alcohols. This method combines hydrogen atom transfer (HAT) catalysis and Lewis acid activation operating under ambient conditions. The protocol exhibits a broad substrate scope and excellent diastereoselectivity, leveraging readily available alcohols as alkyl radical precursors. This sustainable approach provides efficient access to complex heterocyclic scaffolds commonly found in bioactive natural products.
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