Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Modification02:32

Histone Modification

16.2K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.2K
Histone Modification02:32

Histone Modification

4.5K
4.5K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K
Internal Receptors01:31

Internal Receptors

74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.8K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.8K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

111.3K
Overview
111.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RYR:ATP6V0A1 complexes couple ER-lysosome contact sites to dynamic autophagy control.

Autophagy·2026
Same author

Pharmacological and Biological Tools to Inhibit IP<sub>3</sub> Receptors.

Cold Spring Harbor perspectives in biology·2026
Same author

Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers.

Open biology·2026
Same author

Patient-Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy.

Advanced healthcare materials·2026
Same author

Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation.

Nature communications·2026
Same author

Expanding the Early Childhood Manifestations of <i>ITPR1</i> Heterozygous Variants Beyond Congenital Ataxia and Gillespie Syndrome.

Neurology. Genetics·2025
Same journal

Evolutionary and Biochemical Perspectives on the Incorporation and Utilization of Selenocysteine.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Mitochondrial Calcium Uniporter: From Parts to Signaling Networks.

Cold Spring Harbor perspectives in biology·2026
Same journal

Growth Control and Beyond: Functional Diversity and Regulation of the Hippo Pathway in the Nervous System.

Cold Spring Harbor perspectives in biology·2026
Same journal

Structural Studies of Core Hippo Pathway Components.

Cold Spring Harbor perspectives in biology·2026
Same journal

The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis.

Cold Spring Harbor perspectives in biology·2026
Same journal

A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway.

Cold Spring Harbor perspectives in biology·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles
07:54

Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles

Published on: November 5, 2020

5.7K

Control of Inositol 1,4,5-Trisphosphate Receptor Activity by Posttranslational Modifications.

Maarten Vanmunster1, Ian de Ridder1, Manon Callens1

  • 1Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, BE-3000 Leuven, Belgium.

Cold Spring Harbor Perspectives in Biology
|February 9, 2026
PubMed
Summary
This summary is machine-generated.

Posttranslational modifications (PTMs) finely tune inositol 1,4,5-trisphosphate receptors (IP3Rs) activity. These modifications are crucial for regulating calcium (Ca2+) signaling and maintaining cellular homeostasis, impacting various diseases.

More Related Videos

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

13.0K
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
09:01

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC

Published on: June 26, 2020

7.6K

Related Experiment Videos

Last Updated: Feb 11, 2026

Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles
07:54

Purification of Tubulin with Controlled Posttranslational Modifications and Isotypes from Limited Sources by Polymerization-Depolymerization Cycles

Published on: November 5, 2020

5.7K
High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

13.0K
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
09:01

Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC

Published on: June 26, 2020

7.6K

Area of Science:

  • Cellular Biology
  • Molecular Neuroscience
  • Biochemistry

Background:

  • Inositol 1,4,5-trisphosphate receptors (IP3Rs) are critical for calcium (Ca2+) signaling from the endoplasmic reticulum.
  • Dysregulated Ca2+ signaling via IP3Rs is linked to numerous diseases.
  • Tight regulation of IP3R function, abundance, and localization is essential.

Purpose of the Study:

  • To review the diverse posttranslational modifications (PTMs) that regulate IP3R activity.
  • To explore the functional and structural consequences of these PTMs.
  • To highlight isoform-specific effects of PTMs on IP3R regulation.

Main Methods:

  • Literature review focusing on PTMs of IP3Rs.
  • Analysis of functional and structural data related to modified IP3R residues.
  • Synthesis of information on various PTMs including phosphorylation, redox, glycosylation, palmitoylation, ubiquitination, proteolysis, and cross-linking.

Main Results:

  • PTMs such as phosphorylation, redox, glycosylation, palmitoylation, ubiquitination, proteolysis, and cross-linking significantly modulate IP3R activity.
  • Specific PTMs have identified residue targets, providing structural insights.
  • PTMs exhibit isoform-specific regulatory effects on IP3Rs.

Conclusions:

  • PTMs are key regulators of IP3R function, impacting Ca2+ signaling.
  • Understanding these modifications offers a nuanced view of IP3R control in health and disease.
  • Further research into PTMs can reveal therapeutic targets for diseases associated with Ca2+ signaling.