Related Experiment Video
Updated: Feb 11, 2026
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
Published on: January 27, 2026
139
Normothermic machine perfusion applications in kidney transplantation
Matthew L Holzner1, Chris Jaynes2,3, Jacqueline Garonzik-Wang4
1Recanti/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Current Opinion in Organ Transplantation
|February 10, 2026
Summary
Normothermic machine perfusion (NMP) shows promise for kidney transplantation, offering improved preservation and assessment. Further research is needed to establish its superiority over traditional methods for wider clinical adoption.
Area of Science:
- Nephrology
- Transplantation Medicine
- Surgical Technology
Background:
- Normothermic machine perfusion (NMP) is established for liver, lung, and heart transplants but lags in kidney transplantation.
- NMP offers potential benefits including enhanced organ preservation, viability assessment, and mitigation of ischemia-reperfusion injury.
- This review focuses on the evolving applications of NMP in kidney transplantation.
Purpose of the Study:
- To review the current applications of Normothermic Machine Perfusion (NMP) in kidney transplantation.
- To highlight the potential of NMP in improving kidney graft preservation, assessment, and treatment.
- To discuss the challenges and future directions for NMP in clinical kidney transplantation.
Main Methods:
- Review of recent randomized controlled trials and studies on kidney NMP.
- Analysis of feasibility, safety, and outcomes of NMP in kidney transplantation.
- Exploration of advanced applications such as gene therapy and immune modification during perfusion.
Main Results:
- Kidney NMP is demonstrated as feasible and well-tolerated in multiple studies.
- Recent trials show no significant benefit of NMP over cold storage, but NMP may improve logistics and utilization.
- NMP enables assessment and transplantation of marginal kidneys and has supported long-term perfusion of discarded organs.
- In-situ treatments like gene therapy have been successfully performed during kidney NMP.
Conclusions:
- Normothermic perfusion presents diverse applications in kidney transplantation: preservation, assessment, and treatment.
- Standardized perfusion protocols and clear viability criteria are essential for clinical implementation.
- Development of portable, commercially available devices is crucial for broader adoption.
- Comparative studies against current preservation methods are necessary to validate NMP's efficacy.
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