Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Potential and Free Energy02:58

Cell Potential and Free Energy

46.7K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.7K
Autoimmune Disorders01:29

Autoimmune Disorders

1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K
Potential Energy00:52

Potential Energy

42.9K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.9K
Potential Energy01:09

Potential Energy

1.0K
A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
1.0K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.6K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.6K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.5K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supramolecular strategy for compartment pathogen clearance and immuno-metabolic homeostasis to treat periodontitis.

Nature communications·2026
Same author

SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway.

International journal of oral science·2026
Same author

Global and regional burden and inequalities of oral conditions in children, adolescents, and young adults (0-39 years), 1990 to 2021.

PLOS global public health·2025
Same author

Fretibacterium: Exploring Its Pathogenic Potential in Oral Infectious Diseases.

Molecular oral microbiology·2025
Same author

Expert consensus on management of instrument separation in root canal therapy.

International journal of oral science·2025
Same author

Post-Treatment Apical Periodontitis: Endodontic Infection Contributes to Circulating Microbial DNA.

Australian endodontic journal : the journal of the Australian Society of Endodontology Inc·2025
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.3K

B-Cell Landscape in Inflamed Dental Pulp Reveals Potential Autoimmune Involvement.

Y Peng1,2, L Liu1,2, F Yang3

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Journal of Dental Research
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

B cells, previously overlooked in pulpitis, become abundant during inflammation, driving pathology and potentially autoreactivity. Their depletion reduces inflammation, suggesting a key role in dental pulp disease and possible autoimmune links.

Keywords:
antigen presentationautoimmunitygene expressionhistochemistrypulpitissingle-cell sequencing

More Related Videos

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.6K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.5K

Related Experiment Videos

Last Updated: Feb 13, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.3K
In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages
07:32

In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages

Published on: September 25, 2021

3.6K
A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals
08:06

A Co-Culture Method to Study Neurite Outgrowth in Response to Dental Pulp Paracrine Signals

Published on: February 14, 2020

6.5K

Area of Science:

  • Immunology
  • Oral Biology
  • Pathogenesis of Pulpitis

Background:

  • Pulpitis involves dynamic immune responses, but B cell roles are understudied.
  • Understanding B cell involvement is crucial for elucidating pulpitis pathogenesis.

Purpose of the Study:

  • To characterize B cells in healthy and inflamed dental pulp.
  • To investigate the role of B cells in pulpitis development and potential autoimmune mechanisms.

Main Methods:

  • Single-cell RNA sequencing and histopathological analysis of dental pulp.
  • B cell depletion models in mice.
  • Multiplex immunofluorescence and flow cytometry for protein validation.
  • Mendelian randomization and serological assays.

Main Results:

  • B cells are scarce in healthy pulp but increase significantly during inflammation, exhibiting antigen presentation and immunoglobulin secretion.
  • B cell depletion ameliorated pulpal inflammation, confirming their proinflammatory role.
  • Four distinct B cell subsets were identified, with transitional B cells showing signs of autoreactivity and elevated autoantibodies detected.

Conclusions:

  • B cells are key players in pulpitis pathogenesis, contributing to local inflammation and potentially systemic immune alterations.
  • Pulpitis may involve autoimmune mechanisms driven by B cell dysfunction.
  • This study provides a novel cellular atlas and perspective on pulpitis through B cell characterization.