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Updated: Feb 13, 2026

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Effect of the G-Protein-Coupled Receptor T2R14 on Proliferation and Cell Population Growth in Oral Cancer Cells

Yongqiang Chen1, Manikanta Kella1, Kayla Austin1

  • 1Manitoba Chemosensory Biology Research Group, Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.

Cells
|February 12, 2026
PubMed

Insights

Taste receptor type 2 member 14 (T2R14) plays a tumor-suppressor role in oral cancer. Its downregulation increases oral cancer cell proliferation and growth, suggesting T2R14 as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Oral cancer is a significant cause of cancer mortality with unclear mechanisms and suboptimal treatments.
  • The G-protein-coupled receptor, taste receptor type 2 member 14 (T2R14 or TAS2R14), is found in various cancers, but its role in oral cancer is largely unexplored.

Purpose of the Study:

  • To investigate the impact of T2R14 on the proliferation and cell population growth (CPG) of oral cancer cells.
  • To determine if T2R14 functions as a tumor suppressor or promoter in oral cancer.

Main Methods:

  • TAS2R14 gene knockout in oral cancer cells.
  • Measurement of cell numbers, cell viability, and colony formation.
  • Assessment of calcium mobilization and proliferation markers (PCNA, p-mTOR).

Main Results:

  • TAS2R14 knockout decreased calcium mobilization but increased cell numbers, colony formation, and proliferation marker expression.
  • Cell viability was not significantly affected by TAS2R14 knockout.
  • Clinical data showed higher TAS2R14 mRNA expression correlated with better patient survival.

Conclusions:

  • T2R14 downregulation enhances oral cancer cell population growth, indicating a tumor-suppressor-like function.
  • These findings suggest T2R14 as a potential therapeutic target for improving oral cancer treatment strategies.
Keywords:
G-protein-coupled receptorcell population growthcell viabilitycolony formationoral canceroral squamous cell carcinomaproliferating cell nuclear antigentaste receptortaste receptor type 2 member 14

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