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Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

3.4K
Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Related Experiment Video

Updated: Feb 14, 2026

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
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Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

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Chemoprevention in Skin Cancer: What Advice?

Ariadna Ortiz-Brugués1, Carmen Orte Cano2, Lluis Corbella1

  • 1Hospital Clínic Barcelona, 08036 Barcelona, Spain.

Cancers
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Skin cancer incidence is rising globally. Chemopreventive therapies show promise for non-melanoma skin cancers, but further research is needed for aggressive melanoma and other rare skin cancers.

Keywords:
5-fluorouracilactinic keratosischemopreventionmelanomanicotinamidenon-melanoma skin cancerphotodynamic therapyretinoidsskin cancersolid organ transplant recipients

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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Cell Population Analyses During Skin Carcinogenesis
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Cell Population Analyses During Skin Carcinogenesis
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Area of Science:

  • Dermatology
  • Oncology
  • Preventive Medicine

Background:

  • Global incidence of melanoma and non-melanoma skin cancers (NMSCs) is increasing.
  • Melanoma is more aggressive and challenging than NMSCs.
  • Sunscreens offer limited protection, necessitating alternative solutions.

Purpose of the Study:

  • To review current evidence on chemopreventive therapies for skin cancers.
  • To assess the efficacy and adverse events of these therapies.
  • To include data on both immunocompetent and immunosuppressed patients.

Main Methods:

  • Literature review of chemopreventive therapies for skin cancers.
  • Analysis of efficacy and adverse event data.
  • Inclusion of studies involving diverse patient populations.

Main Results:

  • Acitretin, nicotinamide, 5-fluorouracil, and photodynamic therapy show promise for actinic keratosis and squamous cell carcinoma.
  • These therapies have demonstrated overall promising results in specific NMSCs.
  • Efficacy data is limited for melanoma, Merkel cell carcinoma, and cutaneous lymphoma.

Conclusions:

  • Chemopreventive therapies offer potential benefits for certain skin cancers.
  • Further research is crucial to establish efficacy for high-mortality skin cancers like melanoma.
  • More studies are needed to optimize treatment strategies for all skin cancer types.