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Updated: Feb 14, 2026
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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
556
Polymeric Membrane-Based Systems in Transdermal Drug Delivery.
Laura Donato1, Paola Bernardo1
1Institute on Membrane Technology "Enrico Drioli" (National Research Council of Italy), 87036 Rende, Italy.
Polymers
|February 13, 2026
Summary
Controlled drug delivery systems (CDDSs) offer precise therapeutic treatments. Transdermal drug delivery systems (TDDSs) provide a non-invasive route, enhancing patient compliance and reducing side effects through advanced membrane technologies.
Area of Science:
- Polymer Chemistry
- Materials Science
- Membrane Technology
- Pharmaceutical Sciences
Background:
- Controlled drug delivery systems (CDDSs) are crucial for precise and customized disease treatment.
- Transdermal drug delivery systems (TDDSs) offer a non-invasive alternative to oral administration, bypassing gastric issues and first-pass metabolism.
- Developing effective TDDSs requires a multidisciplinary approach, integrating polymer chemistry, materials science, and pharmaceutical sciences.
Purpose of the Study:
- To provide a comprehensive overview of controlled drug delivery systems.
- To focus on transdermal drug delivery systems (TDDSs) from a membrane engineering perspective.
- To discuss materials and strategies for polymeric membrane-based TDDSs.
Main Methods:
- Review of existing literature on controlled and transdermal drug delivery systems.
- Analysis of passive and active transdermal delivery strategies.
- Discussion of various transdermal membrane-based release systems, including patches, mixed-matrix membranes, and imprinted membranes.
Main Results:
- TDDSs utilize the skin for non-invasive drug administration, improving patient compliance and avoiding systemic side effects.
- Polymeric membranes are key components in TDDS formulation, requiring expertise in polymer chemistry and materials science.
- Both passive and active strategies, along with diverse membrane-based systems, are employed for effective transdermal drug delivery.
Conclusions:
- Transdermal drug delivery systems (TDDSs) represent a significant advancement in controlled drug delivery, offering enhanced therapeutic outcomes.
- Membrane engineering plays a vital role in the design and optimization of TDDSs.
- The integration of various scientific disciplines is essential for the continued innovation and application of TDDS technology.
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