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Related Concept Videos

Position-effect Variegation02:32

Position-effect Variegation

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Position and Displacement01:31

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The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
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Serial Position Effect01:03

Serial Position Effect

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The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
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Position Vectors01:29

Position Vectors

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A position vector is a fundamental concept in mathematics that helps determine the position of one point with respect to another point in space. It is a vector that describes the direction and distance between two points. Position vectors are highly useful in the field of math and science, as they help represent spatial relationships and make calculations easier.
For instance, we want to locate a point P(x, y, z) relative to the origin of coordinates O. In that case, we can define a position...
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Anatomical Positions01:11

Anatomical Positions

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In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
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Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

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Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
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Updated: Feb 14, 2026

Preparation of a Blood Culture Pellet for Rapid Bacterial Identification and Antibiotic Susceptibility Testing
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Likelihood of Blood Culture Positivity Using SeptiCyte RAPID.

Krupa A Navalkar1, Alyse Wheelock2, Melissa Gregory2

  • 1Immunexpress Inc., Seattle, WA 98109, USA.

Journal of Clinical Medicine
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

The SeptiCyte RAPID test can help predict positive blood cultures in sepsis patients. Elevated SeptiScores indicate a higher likelihood of bloodstream infection, aiding clinical decisions, especially in resource-limited settings.

Keywords:
SeptiCyte RAPIDSeptiScoreblood cultureblood stream infectionsepsis

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Area of Science:

  • Clinical microbiology
  • Infectious diseases
  • Diagnostic testing

Background:

  • Early diagnosis of bloodstream infections (BSI) and sepsis is crucial for effective treatment and improved patient outcomes.
  • Current diagnostic methods, like blood cultures, can be time-consuming, posing challenges in resource-limited settings, pandemics, and military field care.
  • There is a need for tools to guide microbiologic diagnostic use in critical care scenarios.

Purpose of the Study:

  • To investigate the association between SeptiCyte RAPID test results (SeptiScores) and blood culture (BC) findings in patients with suspected sepsis.
  • To determine if SeptiScores can predict the likelihood of a positive blood culture.

Main Methods:

  • A post hoc retrospective analysis of individual patient data from three prospective clinical studies conducted in North America, Europe, and Africa.
  • Evaluation of the correlation between SeptiCyte RAPID test results (SeptiScores) and blood culture (BC) results.

Main Results:

  • The SeptiCyte RAPID test demonstrated strong diagnostic performance, with an ROC AUC of 0.91 for BC(+) vs. SIRS and 0.80 for BC(-) vs. SIRS.
  • A significant positive correlation was observed: as SeptiScore increases, the probability of a positive blood culture also increases.
  • A crossover point at SeptiScore 10 was identified, above which patients have a higher probability of a positive blood culture.

Conclusions:

  • Elevated SeptiScores, available before blood culture results, are indicative of increased blood culture positivity.
  • The SeptiCyte RAPID test shows clinical utility in resource-limited settings by potentially improving the efficiency of blood culture practices.
  • This test can aid in patient selection and interpretation of blood culture results for sepsis management.