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Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
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Targeting Programmed Cell Death in Myocardial Ischemia-Reperfusion Injury: Potential Mechanisms and Natural Medicine

Xiaoyu Xuan1, Jilin Fan2, Jingyi Zhang3

  • 1College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Phytotherapy Research : PTR
|February 13, 2026
PubMed

Insights

Natural medicines show promise in treating myocardial ischemia-reperfusion injury (MIRI) by modulating programmed cell death (PCD). This approach offers a potential complementary therapy with fewer side effects for cardiac injury.

Area of Science:

  • Cardiology
  • Pharmacology
  • Cell Biology

Background:

  • Acute myocardial infarction (AMI) is a leading global cause of death.
  • Reperfusion therapy is crucial for saving ischemic heart muscle but can cause myocardial ischemia-reperfusion injury (MIRI).
  • Myocardial cell death is central to irreversible cardiac damage in MIRI.

Purpose of the Study:

  • To outline the roles of various programmed cell death (PCD) pathways in MIRI pathogenesis.
  • To summarize the therapeutic potential and mechanisms of natural medicines targeting PCD in MIRI.
  • To provide a reference for future research and drug development in MIRI treatment.

Main Methods:

  • Review of literature on programmed cell death (PCD) mechanisms in myocardial ischemia-reperfusion injury (MIRI).
  • Analysis of studies investigating natural medicines for MIRI treatment.
  • Exploration of the role of apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis in MIRI.

Main Results:

  • Multiple PCD pathways, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, are implicated in MIRI.
  • Natural medicines demonstrate potential in treating MIRI by modulating these PCD pathways.
  • These natural therapies offer a promising avenue with potential for fewer side effects.

Conclusions:

  • Targeting programmed cell death (PCD) is a viable strategy for mitigating myocardial ischemia-reperfusion injury (MIRI).
  • Natural medicines represent a promising complementary and alternative therapy for MIRI, warranting further investigation.
  • Understanding the interplay between PCD and natural compounds can guide the development of novel MIRI treatments.

Keywords:
myocardial ischemia–reperfusion injurynatural medicineprogrammed cell deaththerapy

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