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Comparative Analysis of Glomerular Filtration Rate Measurement Techniques: Part 2. Current GFR Measurements.
Clayton T Brady1,2,3, John C Lieske1,3,4, Kianoush Kashani1,3,5
1Medicine.
Kidney360
|February 13, 2026
Summary
Measured glomerular filtration rate (mGFR) is crucial for assessing kidney function. This review covers established and emerging tracers for accurate mGFR, highlighting advancements toward practical, continuous monitoring.
Area of Science:
- Nephrology
- Medical Diagnostics
- Biomedical Engineering
Background:
- Measured glomerular filtration rate (mGFR) is the gold standard for kidney function assessment.
- Estimated GFR methods may be insufficient in certain clinical scenarios.
Purpose of the Study:
- To review exogenous filtration markers for mGFR measurement.
- To discuss the evolution of mGFR techniques toward practicality and responsiveness.
Main Methods:
- Review of established mGFR tracers: inulin, iothalamate, iohexol, radionuclide tracers.
- Examination of emerging fluorescent and near-infrared tracers.
- Analysis of transcutaneous monitoring technologies.
Main Results:
- Established tracers offer accurate mGFR but vary in handling and applicability.
- Emerging tracers and technologies promise rapid or continuous GFR assessment.
- Advancements focus on practicality, scalability, and dynamic monitoring.
Conclusions:
- The field is moving towards more accessible and responsive mGFR measurements.
- Future methods aim to maintain analytical accuracy while improving clinical utility.
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