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Updated: Feb 15, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Pyridine Synthesis via [3 + 2 + 1] Oxidative Cyclization of Enamines, Ethyl Tertiary Amines, and Alcohols:
Chengli Deng1, Jingzhi Cheng1, Zijing Bai1
1Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Material Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Abstract:
A copper-catalyzed [3 + 2 + 1] oxidative cyclization to access functionalized pyridines was descripted. Employing ethyl tertiary amine as a C2 source, alcohol as a C1 source, and easily handled enamines, one new C-N bond and two new C-C bonds are sequentially constructed by the effective functionalization of multiple C(sp3)-H bonds. Besides the readily available raw materials, mild reaction conditions, broad substrate scope, and effective bond-forming strategy, the present approach offers a viable strategy for preparing functionalized pyridines in future organic synthesis.
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