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Updated: Feb 15, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
A conserved, terminal, pro-tumor neutrophil population
Zheng Jin1, Haixia Long2, Bo Zhu3
1Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing 400016, China.
Abstract:
In this issue of Cancer Cell, Bolli et al. leverage a newly developed neutrophil analysis framework to identify CCL3 as a conserved marker for tumor-associated neutrophils (TANs) across human and murine cancers. Using complementary genetic manipulation strategies, they demonstrate that neutrophil-derived CCL3 supports pro-tumor TAN survival within hypoxic tumor niches.
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