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Updated: Feb 15, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
A conserved, terminal, pro-tumor neutrophil population
Zheng Jin1, Haixia Long2, Bo Zhu3
1Institute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing 400016, China.
Researchers identified CCL3 as a key marker for tumor-associated neutrophils (TANs) in human and mouse cancers. This finding reveals how neutrophil-derived CCL3 promotes the survival of pro-tumor TANs in low-oxygen tumor environments.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Tumor-associated neutrophils (TANs) play complex roles in cancer progression.
- Identifying specific markers for TANs is crucial for understanding their function.
- Hypoxic tumor microenvironments influence immune cell behavior.
Purpose of the Study:
- To identify conserved markers for tumor-associated neutrophils (TANs) in both human and murine cancers.
- To investigate the role of identified markers in supporting TAN survival within the tumor microenvironment.
Main Methods:
- Development of a novel neutrophil analysis framework.
- Utilizing genetic manipulation strategies in cancer models.
- Analysis of CCL3 expression in TANs across different cancer types.
Main Results:
- CCL3 identified as a conserved marker for TANs in human and murine cancers.
- Neutrophil-derived CCL3 was shown to support the survival of pro-tumor TANs.
- CCL3's pro-survival role was specifically observed within hypoxic tumor niches.
Conclusions:
- CCL3 is a conserved marker for tumor-associated neutrophils.
- Neutrophil-derived CCL3 is essential for pro-tumor TAN survival in hypoxic tumor niches.
- Targeting CCL3 may offer a therapeutic strategy for modulating TAN function in cancer.
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