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NON-INVASIVE QUANTITATIVE CT PERFUSION OF THE LIVER IN AUTOIMMUNE HEPATITIS

G Battalova1, Y Kalshabay2, Z Zholdybay3

  • 11Asfendiyarov Kazakh National Medical University, Almaty city; 2National Scientific Center of Surgery named after A.N. Syzganov, Almaty city, The Republic of Kazakhstan.

Georgian Medical News
|February 13, 2026
PubMed

Insights

Computed tomography (CT) perfusion reveals increased arterial flow (AF) and reduced portal flow (PF) in autoimmune hepatitis (AIH). These hemodynamic changes, evident even in early fibrosis, can serve as non-invasive markers for AIH liver injury.

Area of Science:

  • Hepatology
  • Radiology
  • Medical Imaging

Background:

  • Computed tomography (CT) perfusion is a non-invasive method for assessing liver hemodynamics.
  • Evidence for CT perfusion in autoimmune hepatitis (AIH) is limited compared to viral hepatitis.
  • AIH-related liver injury can lead to significant hemodynamic alterations.

Purpose of the Study:

  • To compare CT perfusion parameters (arterial flow [AF], portal flow [PF], perfusion index [PI]) in patients with AIH-related fibrosis and cirrhosis versus healthy controls.
  • To evaluate the potential of CT perfusion parameters as non-invasive markers of AIH severity.

Main Methods:

  • A single-center prospective study included 21 patients with AIH-fibrosis, 17 with AIH-cirrhosis, and 20 healthy liver donors.
  • CT perfusion parameters (AF, PF, PI) were calculated for all participants.
  • Histological staging (F1-F4) and inflammatory activity grading (A1-A4) were performed.

Main Results:

  • Arterial flow (AF) was significantly elevated in both AIH-fibrosis and AIH-cirrhosis groups compared to controls (p<0.001).
  • Portal flow (PF) was significantly reduced in both AIH-fibrosis and AIH-cirrhosis groups compared to controls (p<0.001).
  • AF and PF showed 95% sensitivity in differentiating AIH patients from controls, with no significant difference between fibrosis and cirrhosis stages.

Conclusions:

  • Increased AF and reduced PF are detectable even at the fibrosis stage of AIH.
  • These hemodynamic changes may serve as valuable non-invasive biomarkers for assessing the severity of AIH-related liver injury.
Abstract

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