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Updated: Feb 16, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Targeting enzyme trafficking: from molecular mechanisms to drug discovery
Huidan Dong1, Yongkang Yuan1, Binru Jia1
1School of Medical Technology, Tianjin University of Traditional Chinese Medicine, 301617 Tianjin, the People's Republic of China.
None:
Enzyme trafficking mediates intracellular enzyme transport and localization, which is pivotal for regulating enzymatic activity and maintaining cellular homeostasis. Its dysregulation is implicated in neurodegenerative diseases, cancer, and metabolic syndromes. This review summarizes recent advances in its molecular mechanisms, focusing on signal peptides, post-translational modifications, and vesicular transport pathways, and explores targeted therapeutic strategies including small molecule modulators, gene editing, and protein engineering. These strategies aim to restore normal enzymatic localization and function, offering promising disease treatment avenues. As a key regulatory node in cellular physiology, pharmacological modulation of enzyme trafficking is expected to advance precision medicine and address unmet clinical needs.
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