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Brain network features predating early alcohol initiation in adolescence.

H Byrne1, R Visontay2, E K Devine2

  • 1The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. hollie.byrne@sydney.edu.au.

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Brain network organization in childhood may predict early alcohol initiation. Adolescents with lower brain network segregation and higher integration at ages 9-10 were more likely to start drinking before age 15.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Adolescent Health

Background:

  • Regional neuroanatomical variability is linked to early alcohol use.
  • The connection between whole-brain network organization and adolescent alcohol initiation is not well understood.

Purpose of the Study:

  • To investigate if structural covariance network (SCN) properties at ages 9-10 predict early alcohol initiation.
  • To examine brain network features that precede alcohol consumption before age 15.

Main Methods:

  • Utilized structural MRI data from the Adolescent Brain Cognitive Development (ABCD) study.
  • Performed SCN analysis based on regional cortical thickness to assess network segregation, integration, and resilience.
  • Compared network properties between early alcohol initiators and non-initiators matched for sociodemographic factors.

Main Results:

  • No significant differences in regional cortical thickness were found between groups.
  • Early alcohol initiators exhibited significantly lower network segregation and higher network integration.
  • These brain network differences were observed prior to alcohol initiation.

Conclusions:

  • Cortical thickness network topology in childhood may serve as a neuroanatomical risk marker for early adolescent alcohol initiation.
  • Brain network organization predicts alcohol initiation independently of regional variability and sociodemographic factors.