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Association Between Depression and Polypharmacy in Older Adults-A Systematic Review and Meta-Analysis.
Yi-Hsin Wang1, Tsung-Yu Tsai2, Hung-Chang Chou3
1Department of Psychiatry MacKay Memorial Hospital Taipei Taiwan.
Depression is strongly linked to polypharmacy in older adults. Integrating mental health care with medication management is crucial for this population.
Area of Science:
- Gerontology
- Psychiatry
- Clinical Pharmacy
Background:
- Depression and polypharmacy are prevalent issues in the elderly population.
- These two conditions may have a significant interrelationship.
Purpose of the Study:
- To systematically review and meta-analyze the association between depression and polypharmacy in older adults.
Main Methods:
- Searched EMBASE, PubMed, Web of Science, and PsycINFO databases.
- Included eight studies (six high-quality, two medium-quality).
- Conducted a random-effects model meta-analysis.
Main Results:
- A significant association was found between depression and polypharmacy (OR = 2.49; 95% CI: 1.88-3.29).
- The association remained consistent across community-based and institutional/clinic-based populations.
Conclusions:
- Depression is demonstrably associated with polypharmacy in older adults.
- Highlights the need for integrated mental health assessments within medication management for the elderly.
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