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18 F-FDG PET/CT in Disseminated Cryptococcosis Mimicking Malignancy With Rib Osteolysis and Chest Wall Invasion
Aparna Mahalik1, Nivedita Kundu, Goriparti Lalitha
1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Disseminated cryptococcosis can mimic lung cancer, presenting as a challenging pseudotumor. 18F-FDG PET/CT imaging proved useful for evaluating this aggressive fungal infection and monitoring treatment response.
Area of Science:
- Medical imaging
- Infectious diseases
- Oncology
Background:
- Disseminated cryptococcosis is a rare fungal infection.
- It can present with symptoms mimicking thoracic malignancies.
- Accurate diagnosis and monitoring are crucial for patient outcomes.
Purpose of the Study:
- To report a case of disseminated cryptococcosis mimicking thoracic malignancy.
- To highlight the role of 18F-FDG PET/CT in evaluating this condition.
- To underscore the utility of 18F-FDG PET/CT in therapeutic monitoring.
Main Methods:
- A 56-year-old male patient with known cryptococcosis was evaluated.
- 18F-FDG PET/CT imaging was performed for response assessment.
- Imaging findings were analyzed for disease characteristics and progression.
Main Results:
- 18F-FDG PET/CT revealed a heterogeneously FDG-avid pleural-based mass with bone destruction and chest wall invasion.
- Pulmonary nodules and nodal disease were also observed.
- Interval imaging showed metabolic regression of adrenal and pulmonary lesions, indicating treatment response.
Conclusions:
- Disseminated cryptococcosis can present as an aggressive pseudotumor, posing diagnostic challenges.
- 18F-FDG PET/CT is a valuable tool for characterizing cryptococcosis.
- 18F-FDG PET/CT aids in monitoring therapeutic effectiveness for disseminated cryptococcosis.
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