Synthesis and Biological Evaluation of N-CF₃ Diaryl Amines

Herein, we reported a one-pot synthesis of N-CF₃ diarylamines using AgSCF₃ and AgF. This work provides a robust protocol for the efficient trifluoromethylation modification of diarylamines, enabling the concise one-pot synthesis of diarylamines bearing a pharmaceutically privileged N-CF₃ unit while demonstrating excellent functional group tolerance and steric hindrance compatibility. The obtained diaryl N-CF₃ compounds were subjected to biological evaluation, and the results revealed that N-CF₃ derivative 2y exhibits good in vitro anti-lung carcinoma activities.