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Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
Published on: December 5, 2025
325
Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of
Antonio José Guillot1, Miquel Martínez-Navarrete2, Jose Alejandro Bernabeu-Martínez2
1Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia; antonio.guillot@uv.es.
Journal of Visualized Experiments : Jove
|February 16, 2026
Summary
Dissolving microneedle array patches (DMAPs) offer a painless, effective way to deliver drugs through the skin. These biocompatible patches dissolve after insertion, releasing medication without sharp waste.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Microneedle array patches (MAPs) are a revolutionary transdermal drug delivery system.
- They overcome the skin's barrier function by piercing the stratum corneum painlessly.
- Dissolving MAPs (DMAPs) are advantageous due to biocompatibility, self-administration, and no sharp waste.
Purpose of the Study:
- To detail the manufacturing and characterization of dissolving microneedle array patches (DMAPs).
- To highlight the advantages of DMAPs for transdermal drug delivery.
- To provide a comprehensive overview of DMAP technology.
Main Methods:
- DMAPs manufactured using solvent casting with negative master molds.
- Drug-loaded polymeric dispersions cast and solidified in molds.
- Characterization includes mechanical properties, water content, skin penetration, drug release, and biocompatibility.
Main Results:
- DMAPs are fabricated via solvent casting, yielding solid microneedle patches.
- Characterization assays confirm mechanical integrity, skin penetration, and drug release capabilities.
- Biocompatibility assessments are crucial for clinical application.
Conclusions:
- DMAPs represent a promising, patient-friendly approach to transdermal drug delivery.
- The solvent casting method is a viable bench-level technique for DMAP production.
- Further characterization ensures safety and efficacy for therapeutic use.
