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Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases
Ning Zhao1, Shiheng Tan1, Qingzhen Fu1
1Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, P.R. China.
Brain and Behavior
|February 17, 2026
Summary
This study investigated genetic links between gut and brain diseases. We found shared genetic factors and causal relationships, highlighting the immune system's role in the gut-brain axis.
Area of Science:
- Genetics
- Neuroscience
- Gastroenterology
Background:
- The gut-brain axis theoretically links intestinal and neurological diseases.
- Genetic basis and causality remain unclear.
Purpose of the Study:
- Investigate genetic correlations between intestinal and neurological diseases.
- Identify shared genetic etiology and causal relationships.
Main Methods:
- Utilized genome-wide association study data from FinnGen and UK Biobank.
- Performed global and local genetic correlation analyses.
- Conducted Mendelian randomization and SNP heritability enrichment analyses.
Main Results:
- Identified positive genetic correlations between irritable bowel syndrome and epilepsy/stroke.
- Found local genetic correlations between ulcerative colitis and multiple sclerosis.
- Discovered shared pleiotropic SNPs and a functional gene.
- Showed causal effect of Crohn's disease on Parkinson's disease.
- Indicated immune cell enrichment for ulcerative colitis and multiple sclerosis.
Conclusions:
- Established global and local genetic correlations and causal links between gut and brain diseases.
- Identified shared pleiotropic loci and genes.
- Highlighted the immune system's critical role in the gut-brain axis.
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