Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

995
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
995
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

540
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
540
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

453
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
453
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

559
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
559

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional mechanical differences in hamstring muscles after removal of surrounding connective tissue.

Journal of biomechanics·2026
Same author

A High Level of Calculated Small Dense Low-Density Lipoprotein Cholesterol Is an Independent Risk Factor for the Progression of Renal Impairment.

Circulation journal : official journal of the Japanese Circulation Society·2026
Same author

Genomic Architecture and Cascade Screening Gaps in Hypertrophic Cardiomyopathy: A Real-World Analysis.

Journal of clinical medicine·2026
Same author

Velocity-Dependent Stress Changes in the Hamstring Muscle-Tendon Complex: A Study Using Human Cadavers.

Translational sports medicine·2026
Same author

Sheath Withdrawal May Represent a Mechanically Vulnerable Phase for Septal Perforation During Left Bundle Branch Area Pacing.

Journal of cardiovascular electrophysiology·2026
Same author

Hip-angle dependent changes in the shear modulus of biceps femoris short head with knee extension.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026

Related Experiment Video

Updated: Feb 20, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

11.9K

Sex-Specific Prognostic Patterns of Sarcopenia Components in Patients With Heart Failure.

Aki Habaguchi1, Satoshi Katano2,3, Toshiyuki Yano4

  • 1Graduate School of Medicine, Sapporo Medical University.

Circulation Journal : Official Journal of the Japanese Circulation Society
|February 18, 2026
PubMed
Summary

Performance-based sarcopenia measures predict mortality in heart failure (HF) patients regardless of sex. However, standard muscle mass thresholds may underestimate risk in women, suggesting a need for sex-specific adjustments.

Keywords:
Heart failureMuscle massMuscle strengthPhysical functionSarcopenia

More Related Videos

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 20, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

11.9K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K

Area of Science:

  • Gerontology
  • Cardiology
  • Muscle Physiology

Background:

  • Sarcopenia, a component of aging, is increasingly recognized in heart failure (HF).
  • The prognostic value of sarcopenia components and potential sex differences in HF patients are not fully understood.

Purpose of the Study:

  • To investigate whether sarcopenia components offer sex-specific prognostic information for mortality in patients with heart failure.
  • To evaluate the performance of different sarcopenia assessment tools in predicting death in HF.

Main Methods:

  • A cohort of 604 heart failure patients (259 women, median age 73) underwent dual-energy X-ray absorptiometry.
  • Mortality data were collected over a median follow-up of 2.18 years.
  • Sarcopenia components including handgrip strength, five times sit-to-stand time (FTSS), Short Physical Performance Battery (SPPB), and appendicular skeletal muscle mass index (ASMI) were assessed.

Main Results:

  • All continuous sarcopenia variables were associated with death in the overall cohort.
  • Asian Working Group for Sarcopenia (AWGS2019) criteria for weak handgrip, prolonged FTSS, and low SPPB strongly predicted mortality; low ASMI did not.
  • While most components showed no significant sex interaction, handgrip strength trended towards stronger association in women. AWGS2019 criteria predicted death in men but not in women.

Conclusions:

  • Performance-based sarcopenia components are valuable for mortality risk stratification in HF patients, independent of sex.
  • Population-derived muscle mass thresholds demonstrated reduced prognostic performance in women.
  • Refining disease-specific or sex-adapted thresholds may improve risk stratification accuracy in heart failure.