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Updated: May 6, 2026
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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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Small molecule biomarkers in infectious disease.
Monica Ness1, Godwin Kwakye-Nuako2, Joseane Godinho2
1Department of Chemistry and Biochemistry, San Diego State University, San Diego, United States; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, United States.
Advances in Clinical Chemistry
|February 18, 2026
Summary
Small molecule biomarkers reveal host responses to infectious diseases, aiding diagnosis and treatment monitoring. Overcoming barriers to clinical use requires technological innovation and validation for broader application.
Area of Science:
- Metabolomics
- Infectious Disease Research
- Biomarker Discovery
Background:
- Infectious diseases profoundly alter host metabolism, creating unique small molecule signatures.
- These metabolic changes present opportunities for developing novel diagnostic and prognostic biomarkers.
Purpose of the Study:
- To explore the generation of small molecule biomarkers during infection.
- To highlight host-pathogen interactions influencing metabolic signatures.
- To discuss challenges and future directions in biomarker translation.
Main Methods:
- Review of small molecule biomarker generation during infection.
- Examination of sample preparation, instrumental platforms, and analytical strategies.
- Presentation of case studies for established and emerging biomarkers.
Main Results:
- Host-pathogen interactions yield distinct small molecule metabolic signatures.
- Various analytical techniques exist for small molecule detection and data processing.
- Significant barriers hinder the clinical translation of many candidate biomarkers.
Conclusions:
- Small molecule biomarkers show promise for infectious disease diagnosis, monitoring, and outcome prediction.
- Technological innovation, cost reduction, and clinical validation are crucial for widespread adoption.
- Interdisciplinary collaboration is key to advancing the clinical utility of these biomarkers.
Keywords:
Analytical methodsBiomarker identificationBiomarkersDiagnosisInfectious diseaseInstrumental methodsMass spectrometryMetabolomicsSmall moleculeTreatment monitoringMore Related Videos
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