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Related Concept Videos

Behavioral Genetics and Its Designs01:23

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
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Genetics and Stillbirth.

Tsegaselassie Workalemahu1, Monica H Wojcik2

  • 1Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.

Clinics in Perinatology
|February 18, 2026
PubMed
Summary
This summary is machine-generated.

Genetic testing, including genome sequencing, can identify causes for unexplained stillbirths. This review explores genetic and epigenetic factors to improve diagnosis and management for future pregnancies.

Keywords:
AutopsyChromosomal microarrayExome sequencingGenome sequencingInheritedStillbirth

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Genomics

Background:

  • Stillbirth impacts over 3 million pregnancies globally, with causes remaining unknown in about half of US cases.
  • Current genetic testing identifies chromosomal abnormalities in 6-13% and Mendelian variants in 5-10% of stillbirths.
  • Advanced genomic approaches offer potential for higher diagnostic yields in stillbirth investigations.

Purpose of the Study:

  • To review current knowledge on genetic and epigenetic factors contributing to stillbirth.
  • To present a clinical framework for refining stillbirth diagnosis.
  • To enhance clinical management strategies for stillbirth in subsequent pregnancies.

Main Methods:

  • Comprehensive literature review of genetic and epigenetic contributions to stillbirth.
  • Analysis of diagnostic yield from chromosomal testing, exome sequencing, and family-based genome sequencing.
  • Development of a clinical framework for stillbirth diagnosis.

Main Results:

  • Genetic testing reveals chromosomal and Mendelian causes in a significant proportion of stillbirths.
  • Family-based genome sequencing shows promise for identifying inherited and de novo pathogenic variants.
  • Epigenetic dysregulation is also recognized as a contributing factor to stillbirth.

Conclusions:

  • Integrating advanced genetic and genomic analyses can increase the diagnostic rate of stillbirth.
  • A refined clinical framework is essential for improved stillbirth diagnosis and management.
  • Understanding diverse genetic and epigenetic factors is crucial for preventing future stillbirths.