Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

617
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
617
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

540
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
540
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

622
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
622
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

493
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
493
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

377
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
377
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The U-CLEAR study: Uncovering hemodynamic and vascular contributors to chronic refractory lower extremity edema.

Phlebology·2026
Same author

Oscillating Wellens Syndrome: Multiple Transitions Between Type A and Type B Patterns Preceding Anterior Myocardial Infarction.

JACC. Case reports·2026
Same author

A snare technique for valve-in-valve transcatheter aortic valve replacement in a stented coarctation of the aorta: a case report.

Frontiers in cardiovascular medicine·2026
Same author

Constrictive Pericarditis Due to Metastatic Squamous Cell Carcinoma: A Rare and Ominous Condition.

JACC. Case reports·2026
Same author

From Shoulder to Heart: Acute Shoulder Pain Leads to a Diagnosis of Fabry Disease.

JACC. Case reports·2026
Same author

Cerebral Metastasis From Recurrent Atrial Myxoma: A Case Report.

The American journal of case reports·2026
Same journal

Managing Rheumatic Mitral Stenosis Complicated by Shock and Cardiac Cirrhosis Beyond Guidelines.

JACC. Case reports·2026
Same journal

Transfemoral TAVR in Chronic Type A Aortic Dissection and Severe Aortic Stenosis.

JACC. Case reports·2026
Same journal

Papillary Endothelial Hyperplasia Mimicking Right Atrial Infective Thrombus: Percutaneous Aspiration and Diagnosis.

JACC. Case reports·2026
Same journal

Inclisiran Response in a Patient With Familial Hypercholesterolemia After Suboptimal Response to Evolocumab.

JACC. Case reports·2026
Same journal

Dual-Level Left Ventricular Outflow Tract Obstruction in an Adult.

JACC. Case reports·2026
Same journal

Combining Renal Autotransplantation and Endovascular Aortic Repair for Abdominal Aortic Aneurysm in an LVAD Patient.

JACC. Case reports·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.4K

Permissive Cardiotoxicity in HER2-Positive Metastatic Breast Cancer With Moderate Left Ventricular Dysfunction.

Humza Rashid1, Pramukh Arun Kumar2, Agnes S Kim2

  • 1School of Medicine, University of Connecticut, Farmington, Connecticut, USA.

JACC. Case Reports
|February 19, 2026
PubMed
Summary
This summary is machine-generated.

Guideline-directed medical therapy (GDMT) can help patients with HER2-positive breast cancer recover cardiac function, allowing continued treatment. Cardio-oncology care balances cancer treatment with heart safety.

Area of Science:

  • Cardio-oncology
  • Breast Cancer Research
  • Cardiovascular Medicine

Background:

  • Permissive cardiotoxicity is a growing concern in HER2-positive breast cancer.
  • Oncologic advantages of HER2-targeted therapies may justify cardiac risks.
Keywords:
BRCA2 mutationGDMTHER2-positive breast cancerechocardiographypermissive cardiotoxicity

More Related Videos

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

2.5K
Slicing and Culturing Pig Hearts under Physiological Conditions
07:54

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

17.9K

Related Experiment Videos

Last Updated: Feb 20, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.4K
High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

2.5K
Slicing and Culturing Pig Hearts under Physiological Conditions
07:54

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

17.9K