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Imaging in MASLD.

Sudhakar K Venkatesh1

  • 1Abdominal Imaging, Division, Radiology, Mayo Clinic, Rochester, MN, USA.

Expert Review of Gastroenterology & Hepatology
|February 20, 2026
PubMed
Summary
This summary is machine-generated.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health issue. Imaging techniques are crucial for early detection, staging, and monitoring of MASLD to improve patient outcomes.

Keywords:
Computed tomographyMR elastographyMRIliver stiffnessshear wave elastographysteatohepatitissteatosisultrasound

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Area of Science:

  • Hepatology
  • Radiology
  • Medical Imaging

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally.
  • MASLD prevalence is increasing, posing risks for cirrhosis, liver cancer, and mortality.
  • Early detection and staging are vital for managing MASLD as new treatments emerge.

Purpose of the Study:

  • To review imaging-based evaluations for MASLD.
  • To emphasize the role of imaging in assessing steatosis, fibrosis, and complications.
  • To discuss advanced quantitative techniques and emerging biomarkers.

Main Methods:

  • Literature search of PubMed and Scopus for peer-reviewed publications (2000-present).
  • Inclusion of clinical trials, expert reviews, and major guidelines.
  • Evaluation of ultrasound, CT, MRI, and advanced elastography techniques.

Main Results:

  • Imaging is central to precision hepatology for MASLD risk stratification.
  • Advanced quantitative techniques like MRI proton density fat fraction and various elastographies are summarized.
  • Emerging biomarkers such as sarcopenia and visceral adiposity are discussed.

Conclusions:

  • Imaging enables comprehensive, noninvasive assessment of MASLD.
  • Integration of clinical data, imaging, and elastography enhances individualized care.
  • Imaging plays a key role in monitoring treatment and predicting outcomes for MASLD patients.