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Updated: May 10, 2026

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
Deoxygenative phosphonation of ketones by titanium
Yuquan Wang1, Kai Yin2, Xiaobo Pang1
1State Key Laboratory of Natural Product Chemistry (SKLAOC), College of Chemistry and Chemical Engineering, Lanzhou University 222 South Tianshui Road Lanzhou 730000 China shuxingzh@lzu.edu.cn.
Abstract:
Tertiary phosphine oxides are ubiquitous motifs with essential roles across synthetic chemistry and life sciences, yet C(sp3)-P coupling remains underdeveloped. Herein, we report an accessible di-oxo-titanium trichloride complex, operating in combination with Mn powder, that enables a deoxygenative C(sp3)-P coupling of ketones with secondary phosphine oxides. The transformation proceeds under mild conditions and shows good compatibility with carbonyl substrates, including cyclic and acyclic ketones, as well as aliphatic aldehydes. Functionalities such as carboxyl, acetal, alkyne, sulfonate, phenol, and alcohol are well tolerated.
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